INVESTIGADORES
SAMBUCETTI Pablo Daniel
artículos
Título:
Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life
Autor/es:
F.H. GOMEZ; SAMBUCETTI, P; NORRY F M
Revista:
BIOGERONTOLOGY
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2016 vol. 17 p. 883 - 892
ISSN:
1389-5729
Resumen:
An extremely high (about 100 %) increasein longevity is reported for a subset of recombinantinbred lines (RILs) of Drosophila melanogaster subjectedto a cyclic heat stress throughout the adult life.Previous work showed that both longevity and heatsensitivity highly differed among RILs. The novel heatstress treatment used in this study consisted of 5 min at38 C applicated approximately every 125 minthroughout the adult life starting at the age of 2 days.In spite of the exceptionally high increase in longevityin a set of RILs, the same heat stress treatment reducedrather than increased longevity in other RILs, suggestingthat heat-induced hormesis is dependent on thegenotype and/or the genetic background. Further, onequantitative trait locus (QTL) was identified for heatinducedhormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was notsignificant in its reciprocal panel (RIL-SH2). The levelof heat-induced hormesis showed a sexual dimorphism,with a higher number of lines exhibiting higherhormesis effects in males than in females. The new heatstress treatment in this study suggests that longevitycan be further extended than previously suggested byapplying a cyclic and mild stress throughout the life,depending on the genotype.
