Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues.

ARCARI AJ; GRYNGARTEN MG; FREIRE AV; BALLERINI MG; ROPELATO MG; BERGADÁ I; ESCOBAR ME

Int J Pediatr Endocrinol

Biomed Central

Lugar: Londres; Año: 2016

1687-9848

BACKGROUND: In girls with Idiopathic Central Precocious Puberty (ICPP) concernhas been raised by the potential impact of GnRH-analogues (GnRHa) treatment onbody weight. We evaluated the effect of GnRHa on Body Mass Index (BMI) in girlswith ICPP according to weight status at diagnosis.METHODS: One hundred seventeen ICPP girls were divided according to pretreatment weight status in: normal weight (NW), overweight (OW) and obese (OB). BMI at one and two years of treatment was assessed. BMI-SDS of 60 patients who reached adultheight (AH) was compared to that of 33 ICPP untreated girls.RESULTS: NW girls significantly increased their baseline BMI-SDS at 1 and 2 yearsof treatment. OW girls only had a significant increment at one year of treatment while OB girls showed no BMI-SDS change. Patients evaluated at AH (at least four years after GnRHa withdrawal) showed a significant decrease on BMI compared tobaseline and a significantly lower BMI than the untreated group.CONCLUSION: In ICPP girls the BMI increase under GnRHa was inversely related tothe pretreatment weight status. In the long term follow-up, no detrimental effectof GnRHa on body weight was observed. BMI-SDS was lower in treated than inuntreated girls.