INVESTIGADORES
KAUFMAN Teodoro Saul
artículos
Título:
The 3,4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids. Results of 20 years of research, uncovering a new family of natural products
Autor/es:
SIMONETTI, S. O.; LARGHI, E. L; KAUFMAN, T. S.
Revista:
NATURAL PRODUCT REPORTS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2016 vol. 33 p. 1425 - 1446
ISSN:
0265-0568
Resumen:
Aspergillusand Penicillium are fungal speciesknown to produce a high diversity of secondary metabolites, many of them endowedof interesting bioactivity. The small but steadily growing family of the naturally-occurring5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids and closelyrelated compounds, which represent the results of various research projectsthat spanned over 20 years and involved scientists from different continents,are covered here. The emphasis is placed on the isolation and chemicalstructures of the different compounds, together with their sourcemicroorganisms, environmental conditions, country or region of origin, andrelevant biological activities. In addition, stereochemical aspects, as well asthe proposed biosynthetic pathways for the different members, and the incipientsynthetic efforts towards some of the compounds or their key intermediates, arediscussed in detail.
