INVESTIGADORES
ACOSTA Gabriela Beatriz
artículos
Título:
Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in
Autor/es:
OGITA, KIYOKAZU; CHIE SUGIYAMA; GABRIELA BEATRIZ ACOSTA; NOBUYUKI KURAMOTO; MAKOTO SHUTO; MASANORI YONEYAMA; YUKARY NAKAMURA; TATSUO SHIBA; TARO YAMAGUCHI
Revista:
NEUROSCIENCE LETTERS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 511 p. 116 - 119
ISSN:
0304-3940
Resumen:
The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous glucocorticoid. The aim of this study was to investigate the regulation of TMT neuroxicity by corticosterone receptors including type I (mineralocorticoid receptor, MR) and type II (glucocorticoid receptor, GR) in adult mice. The systemic injection of TMT at the dose of 2.0 or 2.8 mg/kg produced a marked elevation in the level of plasma corticosterone that was both dose and time dependent. The MR agonist aldosterone had the ability to exacerbate TMT cytotoxicity in the dentate granule cell layer, whereas its antagonist spironolactone protected neurons from TMT cytotoxicity there. In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice.