INVESTIGADORES
AMODEO Gabriela
artículos
Título:
Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
Autor/es:
PEREZ DI GIORGIO JULIANA; GABRIELA SOTO; KARINA ALLEVA; CINTIA JOZEFKOWCIZ; GABRIELA AMODEO; JORGE MUSCHIETTI; NICOLAS AYUB
Revista:
JOURNAL OF MEMBRANE BIOLOGY
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2014 vol. 247 p. 107 - 125
ISSN:
0022-2631
Resumen:
Aquaporins (AQPs) are a family of channel
proteins, which transport water and/or small solutes across
cell membranes. AQPs are present in Bacteria, Eukarya,
and Archaea. The classical AQP evolution paradigm
explains the inconsistent phylogenetic trees by multiple
transfer events and emphasizes that the assignment of
orthologous AQPs is not possible, making it difficult to
integrate functional information. Recently, a novel phylogenetic
framework of eukaryotic AQP evolution showed
congruence between eukaryotic AQPs and organismal trees
identifying 32 orthologous clusters in plants and animals
(Soto et al. Gene 503:165?176, 2012). In this article, we
discuss in depth the methodological strength, the ability to
predict functionality and the AQP community perception
about the different paradigms of AQP evolution. Moreover,
we show an updated review of AQPs transport functions in
association with phylogenetic analyses. Finally, we discuss
the possible effect of AQP data integration in the understanding
of water and solute transport in eukaryotic cells.