INVESTIGADORES
PAGOLA Gabriel Ignacio
artículos
Título:
Crystal structure prediction from first principles: The crystal structures of glycine
Autor/es:
A. M. LUND; G. I. PAGOLA; A. M. ORENDT; M. B. FERRARO; J. C. FACELLI
Revista:
CHEMICAL PHYSICS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 626 p. 20 - 24
ISSN:
0009-2614
Resumen:
Here we present the results of our unbiased searches of glycine polymorphs obtained using the genetic algorithms search implemented in MGAC, modified genetic algorithm for crystals, coupled with the local optimization and energy evaluation provided by Quantum Espresso. We demonstrate that it is possible to predict the crystal structures of a biomedical molecule using solely first principles calculations. We were able to find all the ambient pressure stable glycine polymorphs, which are found in the same energetic ordering as observed experimentally and the agreement between the experimental and predicted structures is of such accuracy that the two are visually almost indistinguishable