INVESTIGADORES
BIGI Fabiana
artículos
Título:
Identification of genetic markers for Mycobacterium pinnipedii through genome analysis
Autor/es:
BIGI F; GARCIA-PELAYO MC; NUNEZ-GARCIA J; PERALTA A; CAIMI KC; GOLBY P; HINDS J; CATALDI A; GORDON SV; ROMANO MI
Revista:
FEMS MICROBIOLOGY LETTERS
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2005 vol. 248 p. 147 - 152
ISSN:
0378-1097
Resumen:
Tuberculosis in seals is caused by Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex. In this study, we evaluated the extent of genetic variability among Mycobacterium bovis and M. pinnipedii by microarray-based comparative genomics. We identified two deletions that are exclusive to M. pinnipedii: PiD1 that removes the orthologues of the M. tuberculosis genes Rv3530c and Rv3531c, and PiD2 that encompasses genes Rv1977 and Rv1978. Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised.