CONICET | Buscador de Institutos y Recursos Humanos

Abstract: Knowledge of pharmacokinetic-pharmacodynamic (PK/PD) properties of antihypertensive drugs may optimizedrug therapy of hypertension. PK/PD modeling of antihypertensive drugs in both basic and clinical research could contributeto drug development and clinical practice in several aspects, including a profound evaluation of the efficacy andsafety of investigational antihypertensive agents, enhancement of preclinical information during the development process,identification of factors that contribute to drug response variability, by allowing a rapid identification of poor or nonrespondersand by helping to determine optimal antihypertensive drug and dose requirements in each hypertensive patient.Although a concentration-response relationship for antihypertensive agents was found in normotensive and hypertensivepatients, there are some limitations in PK/PD modeling of antihypertensive drugs in the clinical setting, including applicationof inadequate pharmacodynamic models and the inability to study large doses of antihypertensive drugs in order todetermine the complete pharmacodynamic range of their antihypertensive effect. Most limitations in the clinical study ofPK/PD models of antihypertensive drugs are not present in basic research, and therefore study of PK/PD models in laboratoryanimals could be of interest. The aim of the present review is to describe the current knowledge of PK/PD modelingof antihypertensive drugs in basic and clinical research and its future applications.

enviar mensaje