Caspofungin-resistant C. tropicalis breakthrough fungemia in high risk hematology patients

GARCIA-EFFRON, GUILLERMO; KONTOYIANNIS, DIMITRIOS P.; LEWIS, RUSSEL E.; PERLIN, DAVID S.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

American Society for Microbiology

Lugar: Washington DC (EEUU); Año: 2008 vol. 52 p. 4181 - 4183

0066-4804

We identified three cases of C. tropicalis breakthrough fungemia occurring in allogeneic stem cell recipients on caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MIC values were identified. Each strain carried a characteristic mutation conferring amino acid substitution within Fks1p hot spot 1. stem cell recipients on caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MIC values were identified. Each strain carried a characteristic mutation conferring amino acid substitution within Fks1p hot spot 1. C. tropicalis breakthrough fungemia occurring in allogeneic stem cell recipients on caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MIC values were identified. Each strain carried a characteristic mutation conferring amino acid substitution within Fks1p hot spot 1.