Caspofungin resistance in Candida glabrata secondary to a FKS1 mutation developed during candidemia treatment

CLEARY, JOHN D.; GARCIA-EFFRON, GUILLERMO; CHAPMAN, STANLEY W.; PELIN, DAVID S.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

American Society for Microbiology.

Lugar: Washington DC (EEUU); Año: 2008 vol. 52 p. 2263 - 2265

0066-4804

We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.