INVESTIGADORES
GARCIA Guillermo Manuel
artículos
Título:
A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus
Autor/es:
ROCHA, ELEOUSA M; GARCÍA-EFFRON, GUILLERMO; PARK, STEVEN; PERLIN, DAVID S.
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
American Society for Microbiology
Referencias:
Lugar: Washington DC (EEUU); Año: 2007 vol. 51 p. 4174 - 4176
ISSN:
0066-4804
Resumen:
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
