INVESTIGADORES
GARCIA Guillermo Manuel
artículos
Título:
Serum differentially alters the antifungal properties of echinocandin drugs.
Autor/es:
PADERU, PADMAJA; GARCÍA-EFFRON, GUILLERMO; BALASHOV, SERGEY; DELMAS, GUILLAUME; PARK, STEVEN; PERLIN, DAVID S.
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
American Society for Microbiology.
Referencias:
Lugar: Washington DC (EEUU); Año: 2007 vol. 51 p. 2253 - 2256
ISSN:
0066-4804
Resumen:
Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.
