INVESTIGADORES
GARCIA Guillermo Manuel
artículos
Título:
Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase
Autor/es:
KAHN NIELSEN, JENNIFER; GARCÍA-EFFRON, GUILLERMO; HSU, MING-JO; PARK, STEVEN; MARR, KIEREN A.; PERLIN, DAVID S.
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
American Society for Microbiology
Referencias:
Lugar: Washington DC (EEUU); Año: 2007 vol. 51 p. 1876 - 1878
ISSN:
0066-4804
Resumen:
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655-->Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.
