In vitro activities of three licensed antifungal agents against spanish clinical isolates of Aspergillus spp

GÓMEZ-LÓPEZ, ALICIA; GARCÍA-EFFRON, GUILLERMO; MELLADO, EMILIA; MONZÓN, ARACELI; RODRÍGUEZ-TUDELA, JUAN LUIS; CUENCA-ESTRELLA, MANUEL

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

American Society for Microbiology

Lugar: Washington DC (EEUU); Año: 2003 vol. 47 p. 3085 - 3088

0066-4804

The aim of the present study was to identify retrospectively trends in the species distributions and the susceptibility patterns of Aspergillus species causing fungal infections in Spanish medical centers from 2000 to 2002. The susceptibilities of 338 isolates to amphotericin B, itraconazole, and voriconazole were tested. Aspergillus fumigatus was the most common species (54.7%), followed by Aspergillus terreus (14.8%) and Aspergillus flavus (13.9%). Non-A. fumigatus species were encountered in 45.3% of the samples studied. The majority of Aspergillus isolates were obtained from respiratory tract specimens, followed by ear and skin samples. The geometric mean (GM) MIC of amphotericin B was 0.56 micro g/ml, and the amphotericin B MIC was >2 micro g/ml for 16 isolates (4.7%). Nine of them were A. terreus. The GM MIC of itraconazole was 0.37, and the itraconazole MIC was >4 micro g/ml for 12 (3.5%) isolates. The voriconazole MICs were also high for 8 of the 12 strains for which itraconazole MICs were high (voriconazole MIC range, 2 to 8 micro g/ml).