INVESTIGADORES
MARTINO Diego Javier
artículos
Título:
The trajectory of neuropsychological dysfunctions in bipolar disorders: a critical examination of a hypothesis.
Autor/es:
STREJILEVICH S.A., SAMAMÉ C., MARTINO D.J.
Revista:
JOURNAL OF AFFECTIVE DISORDERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 175 p. 396 - 402
ISSN:
0165-0327
Resumen:
Objective: The hypothesis of a progressive nature of neuropsychological deficits in bipolar disorders isoften accepted as an axiom by many clinicians and researchers in the field. However, contradictory piecesof data and a number of methodological concerns put it under debate.Method: We reviewed findings from three different approaches to the study of the trajectory of cognitivefeatures in bipolar disorders: longitudinal evaluation of cognition in affected subjects, cross-sectionalneuropsychological assessment of patients belonging to different age groups, and exploration of the risk ofdementia in bipolar subjects.Results: An increased risk of developing dementia was found in bipolar subjects. However, evidence fromcross-sectional studies did not show more severe cognitive deficits in patients with longer illness duration.Furthermore, longitudinal studies revealed that bipolar subjects´ cognitive performance did not changebetween different points in time.Conclusions: After a thorough discussion of these findings and the limitations of the different approaches, weargue that, at present, there is no consistent evidence supporting that bipolar disorders, as a group, have aprogressively deteriorating course of cognitive functions. Furthermore, we highlight the possible influence ofpsychotropic agents and metabolic factors on neuropsychological outcomes. Finally, we discuss the clinicalimplications of these findings and propose targets for forthcoming research.