INVESTIGADORES
MOGLIONI Albertina Gladys
artículos
Título:
Stereodivergent synthesis of the first bis(cyclobutane) b-dipeptides
Autor/es:
S. IZQUIERDO; M. MARTÍN-VILÀ; A. G. MOGLIONI, V. BRANCHADELL AND R. M. ORTUÑO
Revista:
TETRAHEDRON-ASYMMETRY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2002 vol. 13 p. 2403 - 2405
ISSN:
0957-4166
Resumen:
The efficient synthesis of methyl 2-benzyloxycarbonylamino-(1S,2R)-cyclobutane-1-carboxylate starting from 2-methoxycarbonyl-(1R,2S)-cyclobutane-1-carboxylic acid is described. This -amino acid derivative is antipodal with respect to the(1R,2S)-compound that was previously synthesized in our laboratory from the same chiral hemi ester. In turn, these enantiomeric-amino acids have been self-condensed and coupled with one another to provide, respectively, enantiomeric and diastereomericbis(cyclobutane) -dipeptides. These products are the first reported -amino acid oligomers containing two directly linked cyclobutane residues.
