INVESTIGADORES
MOGLIONI Albertina Gladys
artículos
Título:
Stereoselective synthesis of novel cyclobutane dehydro amino acids from (+)-a-pinene
Autor/es:
MOGLIONI, ALBERTINA G.; GARCIA-EXPOSITO, ELENA; MOLTRASIO, GRACIELA Y.; ORTUNO, ROSA M.
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1998 vol. 39 p. 3593 - 3596
ISSN:
0040-4039
Resumen:
Title compds. I [R = Ac, Me3CO2C (Boc), PhCH2O2C (Z)] and II (R = Ac, Z) were prepd. in good overall yields through highly stereoselective Wittig-Horner condensations of suitable phosphonates with enantiopure aldehydes easily obtained from α-pinene as chiral precursor. These products, presenting two asym. carbons, two or four prochiral centers, and appropriate chem. functions, are versatile precursors to a variety of cyclobutane amino acid derivs.
