INVESTIGADORES
IRIBARREN Adolfo Marcelo
artículos
Título:
Synthesis of 9-b-D-arabinofuranosylguanine by combined use of two whole
Autor/es:
ROSARIO MEDICI; ELIZABETH S. LEWKOWICZ; ADOLFO M. IRIBARREN
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2009 vol. 19 p. 4210 - 4212
ISSN:
0960-894X
Resumen:
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Unlike the
preparation of other purine nucleosides, transglycosylation from a pyrimidine
nucleoside and guanine is difficult because of the low solubility of this base.
Thus, another strategy, based on the coupled action of two whole cell
biocatalyzed reactions, transglycosylation and deamination, was used. Enterobacter
gergoviae and Arthrobacter oxydans were employed to synthesize 9-b-D-arabinofuranosylguanine
(AraG), an efficient anti leukemic drug.
