INVESTIGADORES
BIGI Fabiana
artículos
Título:
Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis.
Autor/es:
GARCIA E; BIANCO M; GRAVISACO MJ; ROCHA RV; BLANCO FC; BIGI F
Revista:
Tuberculosis (Edinb)
Editorial:
CHURCHILL LIVINGSTONE
Referencias:
Lugar: ESCOCIA; Año: 2015 vol. 95 p. 186 - 189
ISSN:
1472-9792
Resumen:
In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccination with the double mutant protected mice against challenge with a virulent M. bovis strain.
