BECAS
ARIAS CASSARA Maria Lucrecia
artículos
Título:
Two New Furanoeremophilanes from Senecio santelisis
Autor/es:
ARIAS CASSARÁ M. L.; BORKOSKY, S.; GONZÁLEZ SIERRA, M.; BARDÓN, A.; YBARRA, M. I.
Revista:
Chemistry and Biodiversity
Editorial:
Verlag Helvetica Chimica Acta AG
Referencias:
Lugar: Zurich; Año: 2010 vol. 7 p. 1745 - 1753
ISSN:
1612-1872
Resumen:
From an Argentine collection of Senecio santelisis Phil., the new furanoeremophilanoids, (10βH)-6β-acetoxy-1α-hydroxyfuranoeremophilan-9-one (1) and (10βH)-1α-hydroxy-6β-(propanoyloxy)furanoeremophilan-9-one (2), together with the known (10αH)-6β-acetoxy-1α-hydroxyfuranoeremophilan-9-one (3), (10αH)-1α,6β-diacetoxyfuranoeremophilan-9-one (4), and (10αH)-1α-hydroxy-6β-(propanoyloxy) furanoeremophilan-9-one (5) were isolated. Their structures and relative configurations were established on the basis of spectroscopic analysis. Chloroform extract and pure compounds were evaluated for their antifungal activity. Compound 5 exhibited remarkable mycelial growth inhibition against B. cinerea with an IC50 value of 21.4 μg/ml.
