IIBBA   05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
artículos
Título:
Improvement of the synthetic tri-peptide vaccine (S3Pvac) against porcine Taenia solium cysticercosis in search of a more effective, inexpensive and manageable vaccine
Autor/es:
E. SCIUTTO, G. ROSAS, M. HERNANDEZ, C. CRUZ, A. TOLEDO, A. BLANCAS, G. ACERO, B. HERNANDEZ, J. CERVANTES, R. BOBES, F. A. GOLDBAUM, M. HUERTA, A. DIAZ-OREA, A. FLEURY, A. ALUJA, J. CABRERA, L. HERRERA-ESTRELLA, G. FRAGOSO, C. LARRALDE.
Revista:
VACCINE
Referencias:
Año: 2007 vol. 25 p. 1368 - 1378
ISSN:
0264-410X
Resumen:
Vaccination of pigs may curtail Taenia solium transmission by
reducing the number of cysticerci, the precursors of adult intestinal
tapeworms in humans. Several antigen preparations induce protection
against porcine cysticercosis in experimental settings but only one
subunit vaccine (S3Pvac) has been tested and proved effective in the
field against naturally acquired disease. Besides improving of the
vaccine's effectiveness, significant reductions in production costs and
in the logistics of its administration are necessary for the
feasibility of nationwide control programs.
This review
highlights the development of several versions of S3Pvac aimed to
increase effectiveness, reduce costs and increase feasibility by novel
delivery systems and alternative routes of administration.