INVESTIGADORES
PELLEGRINO VIDAL Rocio
artículos
Título:
Spectrofluorimetric study of phenolic endocrine disruptors in cyclodextrin media
Autor/es:
ROCÍO B. PELLEGRINO VIDAL; GABRIELA IBAÑEZ; GRACIELA ESCANDAR
Revista:
RSC Advances
Editorial:
Royal Society of Chemistry
Referencias:
Lugar: Cambridge; Año: 2015 vol. 5 p. 20914 - 20923
Resumen:
This study focuses on the spectrofluorimetric behavior of bisphenol A (BPA), 4-octylphenol (OP) and 4-nonylphenol (NP) in the presence of native and derivative cyclodextrins (CDs). The weak fluorescence emission bands of these endocrine disrupting compounds in aqueous media are significantly enhanced by b-CD and its hydroxyethyl-, hydropropyl, methyl-, and heptakis(2,6-di-o-methyl)-derivatives. A 1:1 guest : host stoichiometry for most complexes is established, although the additional presence of weak 1:2 complexes is suggested in both BPA?hydroxyethyl?b-CD and BPA?heptakis(2,6-di-o-methyl)?bCD systems. The association constants are calculated by applying a non-linear regression method to the changes brought about by the presence of each CD in the corresponding fluorescence spectra, and these values are corroborated using a Benesi?Hildebrand type equation. The participation of the CD substituents in the inclusion phenomenon is indirectly demonstrated through the comparison of the acidity constant values in the absence and in the presence of b-CD derivatives. On the basis of 1 H-NMR studies, possible structures of the formed complexes are suggested, and the structural information is supplemented by AM1 semiempirical calculations. The potential of the studied complexes in relation to their use for analytical purposes and/or for environmental remediation is discussed.