Bases fisiopatológicas de la epilepsia del lóbulo temporal: estudios en humanos y animales

J. PASTOR, Y.G. UZCÁTEGUI, B. GAL-IGLESIAS, G.J. ORTEGA,R.G. SOLA, L. MENÉNDEZ DE LA PRIDA

REVISTA DE NEUROLOGIA

Año: 2006 vol. 42 p. 663 - 673

0210-0010

Temporal lobe epilepsy (TLE) is the most frequent form of pharmaco-resistant epilepsy in human.Research using material from TLE patients undergoing surgery and animal models has significantly increased in the lastdecade. Development.We review recent findings obtained over the last years from electrophysiological and anatomical studiesin human and animal models of TLE. Data suggest a large heterogeneity and inter-individual variability depending on themodel and the system under study. However, a common principle that appears to underlie the epileptic condition is thereorganization of excitation and inhibition resulting in hyperexcitability. Recent research combining in vitro electrophysiologytogether with depth recordings in vivo and new analytical methodologies is also discussed. Conclusions. A multidisciplinaryapproach using both human and animal models can help to fill gaps in our knowledge and to provide unique insights into thepathophysiology of TLE. [REV NEUROL 2006; 42:]