IIBBA   05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
artículos
Título:
Translation and Silencing in mRNA granules
Autor/es:
PIMENTEL, JERÓNIMO; BOCCACCIO G.L.
Revista:
Frontiers in Molecular Neuroscience
Editorial:
Frontiers
Referencias:
Año: 2014
Resumen:
The
transcriptome at the synapse consists of thousands of messengers encoding
several cellular functions, including a significant number of receptors and ion
channels and associated proteins. The concerted translational regulation of all
these molecules contributes to the dynamic control of synaptic strength.
Cumulative evidence supports that dendritic RNA granules and mRNA-silencing foci
play an important role in translational regulation. Several relevant RBPs
- FMRP; FUS/TLS; TDP-43; Staufen; Smaug; Pumilio; CPEB; HuD; ZBP1; and
DDX6 among others - form granules that contain dormant mRNAs repressed by
multiple pathways. Recent reports indicate that dendritic granules may contain
stalled polysomes, and furthermore, active translation may occur in association
with RNA granules. Here, we discuss the molecules and pathways involved in this
continuum of RNA granules that contain masked mRNAs, mRNAs trapped in inactive
polysomes or mRNAs engaged in translation.