INVESTIGADORES
MARTINO Diego Javier
artículos
Título:
Cognitive fucntion in adulthood and elderly euthymic bipolar patients: a comparisons to test models of cognitive evolution
Autor/es:
STREJILEVICH ,S.A., MARTINO D.J.
Revista:
JOURNAL OF AFFECTIVE DISORDERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 150 p. 1188 - 1191
ISSN:
0165-0327
Resumen:
Objective: NeurocognitivedysfunctionisconsideredasthemainpredictorofoveralloutcomeofBD. The issueofwhetherneurocognitivedysfunctioninBDisprogressive?or not?has becomecriticalinthe effort todefine stagingmodelsforthesedisorders.Dataaboutcognitivedysfunctionevolutionarescarce and contradictory.Whilesomestudiesshowedaprogressivepatternothershavefoundastableformof evolution. Methods: TwentyfourpatientswithBDaged60yearsorolder(E-BD),24patientswithBDaged40years or younger(Y-BD)and20healthycontrolsmatchedbytheE-BDgroupwereevaluatedwithtraditional clinical instrumentsandanextensiveneuropsychologicalbatterywascompleted.WeusedANOVAand Chi-squaredforcomparisons.RawscoreofneurocognitivetaskswastransformedtostandardizedZ-score from thenormativedataofeachtesttoavoidtheeffectofage.InordertodecreasetheriskoftypeI errors, one-waymultivariateanalysisofvariancewasconducted. Results: Despite havinganillnessdurationthatwas4timeslonger,E-BDdidnotdifferintermsofkey cognitivedomainscomparedtoY-BD.Thesedatadonotsupportthehypothesisofaprogressionof cognitivedysfunctionduetoillnesschronicity.
