INVESTIGADORES
MARTINO Diego Javier
artículos
Título:
A quantitative review of neurocognition in euthymic late-life bipolar disorder.
Autor/es:
SAMAME C., MARTINO D.J., STREJILEVICH S.A.
Revista:
BIPOLAR DISORDERS
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2013 vol. 16 p. 633 - 644
ISSN:
1398-5647
Resumen:
Objectives: A sizeable body of work has consistently documented that a
number of euthymic mixed-age bipolar disorder subjects exhibit
prominent impairments in a variety of cognitive domains. By contrast,
knowledge about neuropsychological functioning in elderly patients is
scant, despite being necessary for the adequate treatment of this
population and the understanding of illness evolution. The aim of this
study was to combine findings from the available literature in order to
examine the pattern and extent of cognitive deficits in euthymic late-life
bipolar disorder subjects.
Methods: A literature search was conducted through the online
databases PubMed, ScienceDirect, EBSCO, and Wiley-Blackwell,
covering the period between January 1990 and April 2012. Effect sizes
reflecting patient?control differences for 10 cognitive variables were
extracted from selected investigations and combined by means of metaanalytical
procedures.
Results: No significant patient?control differences were found for global
cognitive status as assessed with the Mini-Mental State Examination and
the Clock Drawing Test. Significant overall effect sizes (Hedges? g) of
between 0.61 and 0.88 were noted for sustained attention, digit span
(forwards and backwards), delayed recall, serial learning, cognitive
flexibility, and verbal fluency (phonemic and categorical).
Conclusions: The extent of cognitive dysfunction in euthymic late-life
bipolar disorder subjects may be, on average, similar to that reported for
remitted young adult patients. Larger effect sizes of impairment may be
associated with late illness onset. Implications and future directions for
research are proposed.