INVESTIGADORES
MARTINO Diego Javier
artículos
Título:
Neurocognitive functioning in early-onset and late-onset older patients with euthymic bipolar disorder
Autor/es:
MARTINO D.J., STREJILEVICH S.A., MANES F.
Revista:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY.
Editorial:
JOHN WILEY & SONS LTD
Referencias:
Lugar: LOndres; Año: 2013 vol. 28 p. 142 - 148
ISSN:
0885-6230
Resumen:
Objective: Most neurocognitive studies have not taken into account the fact that older patients with bipolar disorder (BD) are a heterogeneous population. The main goal of this study was to compare neurocognitive performance and extrapyramidal symptoms in older patients with early-onset BD (EO-BD) and late-onset BD (LO-BD).Methods: Euthymic older patients with EO-BD (n = 20), LO-BD (n = 20), and healthy controls (n = 20) were evaluated with traditional clinical instruments and measures of exposure to psychotropic drugs, as well as extrapyramidal symptoms. All subjects completed an extensive neuropsychological battery.Results: Patients with EO-BD showed poorer performance than healthy controls in two measures of verbal memory and two measures of executive functions, whereas patients with LO-BD exhibited lower performance scores than healthy controls in almost all of the measures assessed. Impairments in the LO-BD group included even neurocognitive domains typically spared in mixed-age patients. Additionally, there was a trend toward displaying higher extrapyramidal symptoms in the LO-BD group compared with both EO-BD and healthy control groups. In both patient groups, psychosocial functioning was related with executive dysfunction and extrapyramidal symptoms.Conclusions: Patients with LO-BD may have more extensive and severe cognitive impairments, as well as higher vulnerability to extrapyramidal symptoms, compared with patients with EO-BD. Cognitive-motor disturbances may help to explain impairments in daily functioning among older patients with EO-BD and LO-BD during remission.