INVESTIGADORES
ISLAN German Abel
artículos
Título:
Alginate Lyase and Ciprofloxacin Co-Immobilization on Biopolymeric Microspheres for Cystic Fibrosis Treatment
Autor/es:
ISLAN GA; BOSIO VE; CASTRO GR
Revista:
MACROMOLECULAR BIOSCIENCE
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Lugar: Weinheim; Año: 2013 vol. 13 p. 1238 - 1248
ISSN:
1616-5187
Resumen:
A new formulation is described based on biopolymeric microspheres containing alginate lyase(AL) and ciprofloxacin (Cip) for sustainable oral delivery in CF patients. Alginate (ALG) andhigh-methoxyl pectin (HMP) are selected as the biopolymers to develop a composite matrix.ALG microspheres coated with HMP and ALG-HMP blend are gelled in water/organic solventsmixtures, obtaining Cip encapsulations from 46.0 to100.0%. ALG-HMP shows a Cip sustainable releaseprofile and is able to encapsulate 90.0% of AL, showing76.0% enzyme activity after release under simulatedintestinal conditions. The developed system is apromising delivery carrier to treat chronic infectionof Pseudomonas aeruginosa and to reduce theviscoelasticity of the mucus accumulated into intestineof CF patients.