INVESTIGADORES
ALTHABE Fernando
artículos
Título:
Use of a rapid test on umbilical cord blood to screen for Trypanosoma cruzi infection in pregnant women in Argentina, Bolivia, Honduras, and Mexico
Autor/es:
SOSA-ESTANI S; GAMBOA-LEÓN MR; DEL CID-LEMUS J; ALTHABE F; ALGER J; ALMENDARES O; CAFFERATA ML; CHIPPAUX JP; DUMONTEIL E; GIBBONS L; PADILLA-RAYGOZA N; SCHNEIDER D; BELIZÁN JM; BUEKENS P
Revista:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Editorial:
AMER SOC TROP MED & HYGIENE
Referencias:
Lugar: Stanford; Año: 2008 p. 755 - 759
ISSN:
0002-9637
Resumen:
We conducted a cross-sectional study of Chagas disease in five endemic areas in Argentina, Bolivia, Honduras, and México to estimate the prevalence of Trypanosoma cruzi-specific antibodies in pregnant women, and to assess the use of a rapid test (Chagas Stat-Pak) to screen for T. cruzi infection at the time of delivery. The prevalence of antibodies to T. cruzi measured by enzyme-linked immunosorbent assay (ELISA) in maternal blood was 5.5% (a range of 0.8-28.8% among the countries) in 2,495 women enrolled. Compared with ELISA in maternal blood samples, the Chagas Stat-Pak rapid test sensitivity and specificity in umbilical cord blood were 94.6% and 99.0%, respectively. These results show the ability for a rapid determination of the presence of T. cruzi-specific antibodies in umbilical cord blood as a pragmatic strategy to screen for infection in pregnant women
