INVESTIGADORES
WALD Miriam Ruth
artículos
Título:
Long-term treatment with fluoxetine associates with peripheral effects on rat vas deferens contractility
Autor/es:
BUSCH L; WALD MR; BORDA E
Revista:
LIFE SCIENCES
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 1999 vol. 64 p. 117 - 123
ISSN:
0024-3205
Resumen:
The aim of this work was
to study whether long-term treatment with fluoxetine could induce peripheral effects
by modifying vas deferens contractile activity. For this purpose the contractile
response to NE, and 5-HT of vas deferens isolated from male Wistar rats that received
fluoxetine 10rng/kg/day ip, during 21 days, was studied using the isolated organ
bath technique. Results show that vas deferens of treated rats presented spontaneous
activity, an effect that was abolished by prazosin and isoproterenol and that was
not affected by nitroprusside or indomethacin. In addition, fluoxetine did not modify
the response to calcium suggesting that spontaneous activity was not a consequence
of an abnormal calcium movement. Fluoxetine induced a significant increase in the
response of vas deferens to 5-HT and to low NE concentrations while NE maximal effect
was unaffected. Fluoxetine treatment did not modify the binding parameters of [3-H]-prazosin
to vas deferens. It is concluded that long-term
treatment with fluoxetine modifies vas deferens contractile activity. This effect
could be the result of an alteration of adrenergic neurotransmission and could account
for some of the untoward effects observed during clinical course with fluoxetine