INVESTIGADORES
WALD Miriam Ruth
artículos
Título:
Fluoxetine modulates norepinephrine contractile effect on rat vas deferens.
Autor/es:
BUSCH L; WALD MR; STERIN-BORDA L; BORDA E
Revista:
PHARMACOLOGICAL RESEARCH
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2000 vol. 41 p. 39 - 45
ISSN:
1043-6618
Resumen:
The aim of this
study was to evaluate whether the antidepressant drug fluoxetine could modify
rat vas deferens response to norepinephrine NE , and to compare its effect with
that of desipramine and cocaine. Results showed that 10 -5 M fluoxetine produced a super-sensibility of vas deferens to NE. This
result was the same as those obtained for 10-6M desipramine or cocaine. Since the effect was
Na - and Cl -dependent, an inhibitory mechanism of neuronal NE transport was
suggested. Fluoxetine did not modify 3H prazosin Kd or Bmax in rat vas deferens, reinforcing the
hypothesis of a pre-synaptic site of action. On the other hand fluoxetine
inhibited NE maximal effect. This inhibitory effect could be related to an
antagonism of calcium entry through the voltage-dependent calcium channel,
since it was partially reverted by increasing calcium concentration and,
besides, the drug was able to inhibit the calcium concentration response curve
also. Contractions induced by 5-hydroxytryptamine 5-HT were not modified in the
presence of fluoxetine. It is concluded that fluoxetine modulates rat vas deferens
response to low NE concentrations in the same manner as the selective inhibitor
of NE neuronal uptake desipramine. This peripheral effect could participate in
the modulation of the male reproductive tract observed by these drugs when used
in clinical trials