The Design, Synthesis and Evaluation of A,C,D-Ring Analogs of the Fungal Metabolite K-76 as Complement Inhibitors: A Potential Probe for the Absolute Stereochemistry at Position 2

TEODORO SAUL KAUFMAN; D SINDELAR, ROBERT; RANJAN P SRIVASTAVA; C MARSH, HENRY; SUSSANE M SCESNEY

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 1995 vol. 5 p. 501 - 506

0960-894X

In an attempt to synthesize stereochemically pure new A, C, D-ring analogs of the natural product complement inhibitor K-76, compounds (20-24) were prepared and the representative one (23) was evaluated for its ability to inhibit complement-mediated erythrocyte lysis in both the classical and alternative pathways. Compounds synthesized as part of this study suggest that the terpenoid diol component of K-76 may not be essential for complement inhibition.