Synthesis of the Tetrahydroisoquinoline Unit in the Ab Ring- System of the Novel Antitumor-Antibiotic Tetrazomine

PONZO, VL; TEODORO SAUL KAUFMAN

JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS 1

RSC

Lugar: Londres; Año: 1997 vol. 21 p. 3131 - 3133

The elaboration of a polysubstituted 7-amino tetrahydroisoquinoline derivative which embodies the central AB ring system of the novel antitumor-antibiotic tetrazomine, employing a highly selective ortho nitration and Jackson tosylamido acetal cyclisation as crucial steps, is reported