Approaches to the Total Synthesis of Calycotomine, a Widespread 1-Hydroxymethyl-Substituted Simple Tetrahydroisoquinoline

TEODORO S. KAUFMAN

SYNTHESIS-STUTTGART

Thieme

Lugar: Stutgart; Año: 2005 p. 339 - 360

0039-7881

 1-Hydroxymethyl-substituted tetrahydroisoquinolines are scarce in nature; the widespread alkaloid calycotomine is its most prominent example. The different total syntheses of this natural product, used as test ground for the development of novel synthetic methodologies during the last forty years, and those of some structurally related precursors, are reviewed.