Synthesis of Tricyclic Analogs of Stephaoxocanidine and Their Evaluation as Acetylcholinesterase Inhibitors

DARÍO A. BIANCHI; GUILLERMO SCHMEDA HIRSCHMANN; CRISTINA THEODULOZ; ANDREA B. J. BRACCA; TEODORO S. KAUFMAN

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elsevier

Lugar: Amsterdam; Año: 2005 vol. 15 p. 2711 - 2715

0960-894X

  The synthesis of simplified analogs of the novel isoquinoline alkaloid stephaoxocanidine, carrying the oxazaphenalene ABC-ring system of the natural product, and their activity as inhibitors of the enzyme acetylcholinesterase, are reported. 5,6-Dimethoxy- 7H -8-oxa-1-aza-phenalen-9-one (5) was as active as a Narcissus extract enriched in galantamine.