INVESTIGADORES
KAUFMAN Teodoro Saul
artículos
Título:
A Chemometric Method for the Simultaneous Determination of Acetaminophen and Diclofenac in Pharmaceutical Preparations
Autor/es:
SILVANA E. VIGNADUZZO; RUBÉN M. MAGGIO; PATRICIA M. CASTELLANO; TEODORO SAUL KAUFMAN
Revista:
Analytical And Bioanalytical Chemistry
Editorial:
Springer
Referencias:
Lugar: Alemania; Año: 2005 vol. 382 p. 1711 - 1714
ISSN:
1618-2642
Resumen:
A new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test.
