INVESTIGADORES
KAUFMAN Teodoro Saul
artículos
Título:
Evaluación y Análisis de Parámetros de Calidad de Comprimidos de Paracetamol
Autor/es:
OPERTO, M. A.; CASTELLANO, P. M.; KAUFMAN, T. S.
Revista:
ACTA FARM. BONAERENSE
Editorial:
CFPBA
Referencias:
Lugar: Buenos Aires; Año: 2008 vol. 27 p. 603 - 607
ISSN:
0326-2383
Resumen:
With the aim of performing a comparative
evaluation of quality characteristics of acetamoniphen tablets (500 mg),
mechanic, bioavailability and posology-related quality
parameters were studied on 10 different commercial brands, employing tests prescribed by the USP
30, the BP 2007 and the FA VII Ed. These included friability, disintegration,
dissolution and uniformity of dose units, besides the assay of the
active principle. Nine of the brands complied with all of the tests, while one
brand failed in the friability test. Despite that all brands complied with the
dissolution test, notorious variations in their dissolution
profiles were observed, probably as a result of differences in the quali-quantitative composition
of the excipients in the formulae and the pharmaceutical technology employed