INVESTIGADORES
MARTIN Gabriela Adriana
artículos
Título:
Diabetes and cancer: experimental model induced in rats
Autor/es:
C. COCCA, G. MARTIN, E. RIVERA, C. DAVIO, G. CRICCO, B. LEMOS, C. FITZSIMONS, A. GUTIERREZ, E. LEVIN, R. LEVIN, M. CROCI AND R. BERGOC
Revista:
EUROPEAN JOURNAL OF CANCER
Editorial:
Elsevier
Referencias:
Lugar: Oxford, England ; Año: 1998 vol. 34 p. 889 - 894
ISSN:
0959-8049
Resumen:
The aim of this study was to develop an experimental model for the study of cancer associated with diabetes. For diabetes induction, Sprague±Dawley rats were given streptozotocin (STZ, 90 mg/kg body weight (BW)), by intraperitoneal injection on the second day of life. For mammary tumour induction, rats were injected with 50 mg/kg BW of N-nitroso-N-methylurea (NMU) at 50, 80 and 110 days old. The neoplastic process and the eVect of tamoxifen treatment was examined in non-diabetic and diabetic rats. The latency period, NMU-induced tumour incidence and the number of tumours per rat in diabetic rats versus controls were 117 . 7 days versus 79 . 9 days (P < 0.001); 93% versus 95% (NS); and 5.2 . 1.6 versus 2.7 .0.5 (P <0.02). A more benign histological pattern for tumours in diabetic animals was observed. Mammary tumours in diabetic rats grew more slowly than in controls. Tamoxifen (1 mg/kg/day) treated diabetic rats showed tumour regression in 67% of NMU-induced mammary tumours versus 53% in controls (NS). Our results show that tumour progression seems to be aVected by diabetes in this experimental model. We suggest this is the result of changes to insulin-like growth factors and their receptors, which occur in diabetics, and our future research will examine this hypothesis.N-nitroso-N-methylurea (NMU) at 50, 80 and 110 days old. The neoplastic process and the eVect of tamoxifen treatment was examined in non-diabetic and diabetic rats. The latency period, NMU-induced tumour incidence and the number of tumours per rat in diabetic rats versus controls were 117 . 7 days versus 79 . 9 days (P < 0.001); 93% versus 95% (NS); and 5.2 . 1.6 versus 2.7 .0.5 (P <0.02). A more benign histological pattern for tumours in diabetic animals was observed. Mammary tumours in diabetic rats grew more slowly than in controls. Tamoxifen (1 mg/kg/day) treated diabetic rats showed tumour regression in 67% of NMU-induced mammary tumours versus 53% in controls (NS). Our results show that tumour progression seems to be aVected by diabetes in this experimental model. We suggest this is the result of changes to insulin-like growth factors and their receptors, which occur in diabetics, and our future research will examine this hypothesis.Vect of tamoxifen treatment was examined in non-diabetic and diabetic rats. The latency period, NMU-induced tumour incidence and the number of tumours per rat in diabetic rats versus controls were 117 . 7 days versus 79 . 9 days (P < 0.001); 93% versus 95% (NS); and 5.2 . 1.6 versus 2.7 .0.5 (P <0.02). A more benign histological pattern for tumours in diabetic animals was observed. Mammary tumours in diabetic rats grew more slowly than in controls. Tamoxifen (1 mg/kg/day) treated diabetic rats showed tumour regression in 67% of NMU-induced mammary tumours versus 53% in controls (NS). Our results show that tumour progression seems to be aVected by diabetes in this experimental model. We suggest this is the result of changes to insulin-like growth factors and their receptors, which occur in diabetics, and our future research will examine this hypothesis.P < 0.001); 93% versus 95% (NS); and 5.2 . 1.6 versus 2.7 .0.5 (P <0.02). A more benign histological pattern for tumours in diabetic animals was observed. Mammary tumours in diabetic rats grew more slowly than in controls. Tamoxifen (1 mg/kg/day) treated diabetic rats showed tumour regression in 67% of NMU-induced mammary tumours versus 53% in controls (NS). Our results show that tumour progression seems to be aVected by diabetes in this experimental model. We suggest this is the result of changes to insulin-like growth factors and their receptors, which occur in diabetics, and our future research will examine this hypothesis.P <0.02). A more benign histological pattern for tumours in diabetic animals was observed. Mammary tumours in diabetic rats grew more slowly than in controls. Tamoxifen (1 mg/kg/day) treated diabetic rats showed tumour regression in 67% of NMU-induced mammary tumours versus 53% in controls (NS). Our results show that tumour progression seems to be aVected by diabetes in this experimental model. We suggest this is the result of changes to insulin-like growth factors and their receptors, which occur in diabetics, and our future research will examine this hypothesis.Vected by diabetes in this experimental model. We suggest this is the result of changes to insulin-like growth factors and their receptors, which occur in diabetics, and our future research will examine this hypothesis.