INVESTIGADORES
MANUCHA Walter Ariel Fernando
artículos
Título:
THE WORLD PANDEMIC OF VITAMIN D DEFICIT COULD POSSIBLY BE EXPLAINED BY CELLULAR INFLAMMATORY RESPONSE ACTIVITY INDUCED BY THE RENIN ANGIOTENSIN SYSTEM
Autor/es:
MARCELO FERDER; FELIPE INSERRA; WALTER MANUCHA; LEÓN FERDER
Revista:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Editorial:
AMER PHYSIOLOGICAL SOC
Referencias:
Año: 2013 vol. 304 p. 1027 - 1039
ISSN:
0363-6143
Resumen:
There is a functional interaction between the VDR and the RAS. Increased RAS activity and lower activation of the VDR can be complementary situations, and the intervention on one of them seems to be change, in the opposite direction, the other factor. Thus, the process could underlie a probable causal relationship. In fact, the pandemia of vitamin D deficiency could be the other face of increased RAS activity, which probably causes a lower activity or lower levels of vitamin D. To make this more likely a close spatial interaction between the two systems would be necessary. We have shown that almost all tissues that express VDR express also Ang II receptors. This co-expression appears to be present also in mitochondria, which is basically where cellular energy is generated and where cellular signals are triggered resulting in the oxidative changes associated with chronic inflammatory processes, especially in the cardiovascular and renal systems. RAS blockade or stimulation VDR produces similar changes on these oxidative inflammatory disorders. Moreover, the combination of both strategies appears to be more effective than each one used individually. It is possible that this is due, at least in part, to a more effective blockade action over the RAS cascade, especially at the cellular level and particularly at the mitochondrial level. It is necessary to design more studies to confirm this therapeutic option, which could represent a substantial advantage in terms of protecting the function of tissue and vital organs.