INVESTIGADORES
CAVATORTA Ana Laura
artículos
Título:
Differential expression of PDZ-containing proteins in human diseases: challenging topics and novel issues
Autor/es:
FACCIUTO FLORENCIA; CAVATORTA ANA LAURA; BUGNON VALDANO MARINA; MARZIALI, FEDERICO; GARDIOL DANIELA
Revista:
FEBS JOURNAL
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2012 vol. 279 p. 3538 - 3548
ISSN:
1742-464X
Resumen:
The general features of the PDZ domain structure and functions have been
extensively studied during the last decade. PDZ domains are generally present
in proteins that are involved in multiple interactions to assemble functional
protein complexes that control key cellular processes. One of the
best characterized functions of PDZ domain-containing proteins is control
of epithelial cell polarity and cellcell contacts. In the present review, we
summarize the current knowledge on regulation of expression of certain
PDZ polarity proteins localized at the intercellular junctions. In addition,
we provide a critical overview of recent findings regarding the role of these
proteins during development of human diseases. Complete understanding
of these issues is valuable for the design of novel therapeutic intervention
for common pathologies, such as cancer.