Respuesta inmune en terneros experimentalmente infectados con diferentes dosis de Mycobacterium bovis

BLANCO, F.C; BIANCO, M.V; MEIKLE, V; GARBACCIO, S; VAGNONI, L; CATALDI, A. A; BIGI F

RIA

RIA

Lugar: Buenos Aires; Año: 2011 vol. 37 p. 189 - 192

1669-2314

Mycobacterium bovis, the causative agent of bovine tuberculosis, infects animals of agricultural importance and others mammals, including humans. Therefore, this disease causes significant economical losses and is a public health hazard. To better understand the immune response against M. bovis in cattle, in this study we characterized the immunological profile towards M. bovis antigens in cattle experimentally infected at various doses of a virulent M. bovis strain by measurement of IFN-ɣ production in peripheral blood mononuclear cells and by determining which lymphocyte subsets are involved in recall responses of peripheral blood mononuclear cells from infected cattle to M. bovis antigens. We found that the level of CD4 cell activation is similar among infected group irrespectively of the doses used to infect the animals, while activation of CD8 cells is dose-dependent. We also found that the production of IFN-ɣ in peripheral blood mononuclear cells after specific stimuli is not associated with the bacterial counts in the infectious doses.