INVESTIGADORES
MALIRAT Viviana
artículos
Título:
First full-length genomic sequence of a hepatitis A virus isolated in Argentina shows recombination between subgenotypes IA and IB
Autor/es:
AGUIRRE, SEBASTIAN; MALIRAT, VIVIANA; SCODELLER, EDUARDO; MATTION, NORA
Revista:
VIRUS RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 155 p. 316 - 324
ISSN:
0168-1702
Resumen:
A hepatitis A virus (HAV) recovered in Argentina from a stool sample of a sick child in the year 2006 (HAVArg/
06)wasentirely sequenced. Phylogenetic analysis included the HAV-Arg/06 sequence in subgenotype
IA, either considering the usual VP1-2A variable junction fragment or the full length nucleotide sequence.
Interestingly, a recombination event with subgenotype IB, involving a portion of the 2C3A nonstructural
proteins coding region (nucleotides 49615140) was detected using specific software. Only subgenotype
IA strains have been detected in Argentina or Uruguay, whereas subgenotype IA and IB strains have been
reported to circulate in Brazil. Although recombination has been given an important role in the evolution
of picornaviruses, there have been only a few reports of its involvement in the evolution of HAV, probably
due to the limited number of complete HAV sequences available. This study constitutes the first report
of a full-length HAV sequence in Argentina and the third in South America, after the sequence of the IA
isolate HAV5 from Uruguay and the IB isolate HAF-203 from Brazil. The availability of new sequence data
covering the complete HAV genome will help establish a more consistent genetic relatedness among HAV
isolates and the role of recombination in its evolution.