INVESTIGADORES
CROCI RUSSO Diego Omar
artículos
Título:
Tumor Immune Escape Mechanisms that Operate During Metastasi.
Autor/es:
CROCI DO; SALATINO M
Revista:
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Año: 2011
ISSN:
1389-2010
Resumen:
mmune cells actively influence, among other factors, each step of tumor
development determining the chance of a cancer cell to survive in a
threaten microenvironment. Antitumor immune-mediated mechanisms are
activated as soon as the first cancer cell is detected and operate both
during primary tumor formation and during metastasis. However, when both
innate and adaptive immunity becomes impaired, tumor development
occurs. In this sense, compelling evidences indicate that tumor cells
employ mechanisms that circumvent or thwart the immune response to
enhance their own growth. These mechanisms include the secretion of
immunosuppressive factors and the induction of distinct regulatory
lymphoid or myeloid cells and, as occur with the immune response, they
operate both during primary tumor formation and metastasis.
Interestingly, cellular and molecular mechanisms of the immune response
are important components of the tumor microenvironment and have the
ability to promote or suppress tumor progression depending of the
context of each cell interaction. In that sense, researchers are
focusing their attention in the study of the influence of the tumor
microenvironment in tumor growth and metastasis to better understand
cancer biology and to formulate novel therapeutic approach. This review
will focus on the present knowledge about interaction between immune
cells and tumors in the context of metastasis, discussing the
participation of different components of innate and adaptive immune
response in the process of metastasis formation and dissemination.