INVESTIGADORES
SORTINO Maximiliano Andres
artículos
Título:
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino DielsAlder reactions
Autor/es:
CARLOS MELENDEZ; VLADIMIR V. KOUZNETSOV; MAXIMILANO SORTINO; SANDRA ALVAREZ; SUSANA ZACCHINO
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Elsevier
Referencias:
Lugar: Estados Unidos; Año: 2008 vol. 16 p. 7908 - 7920
ISSN:
0968-0896
Resumen:
Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino DielsAlder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds.
