An update on Mycobacterium tuberculosis lipoproteins

BIGI M; FORRELLAD MA; JULIA SABIO Y GARCÍA; BLANCO F; VAZQUEZ, CRISTINA L.; BIGI F.

Future Microbiology

Newlands Press Ltd

Año: 2023 vol. 18 p. 1381 - 1398

AbstractAlmost 3% of the proteins of Mycobacterium tuberculosis (M. tuberculosis), the main causative agent of human tuberculosis, are lipoproteins. These lipoproteins are characteristic of the mycobacterial cell envelope and participate in many mechanisms involved in the pathogenesis of M. tuberculosis. In this review, the authors provide an updated analysis of M. tuberculosis lipoproteins and categorize them according to their demonstrated or predicted functions, including transport of compounds to and from the cytoplasm, biosynthesis of the mycobacterial cell envelope, defense and resistance mechanisms, enzymatic activities and signaling pathways. In addition, this updated analysis revealed that at least 40% of M. tuberculosis lipoproteins are glycosylated.