Camera-based CW diffuse optical tomography for obtaining 3D absorption maps by means of digital tomosynthesis

NACARBONE, D A VERA, D I IRIARTE, J A POMARICO, R MACDONALD AND D GROSENICK

Biomedical Physics and Engineering Express

IOP Publishing Ltd

Año: 2020 vol. 6

Wepresent a novel method for obtaining a 3Dabsorption map of a tissue-like turbid slab in the nearinfraredspectral range by tomosynthesis. Transmittance data are obtained for a large number ofoblique projection directions by scanning a cwlaser source across the surface of the slab and by using aCCDcamera for spatially resolved light detection. A perturbation model of light transport is used toconvert the intensity maps for the different projections into absorption maps. By applying thetomosynthesis approach to these new maps, 3D absorption information on embedded inclusions hasbeen obtained for the first time. The number and the positions of the lateral offset detectors have beenoptimized by employing a structural similarity index for comparison of the reconstructed with thetrue absorption data.Wepresent 3D reconstruction of absorption maps using both Monte Carlosimulations and experiments on phantoms with breast-like optical properties. A comparison withconventional 3D reconstruction by a finite element approach shows the superior locationperformance of tomosynthesis.