INVESTIGADORES
RIOS Hugo
artículos
Título:
Long-lasting effects of neonatal ionizing radiation exposure on spatial memory and anxiety-like behavior.
Autor/es:
CÁCERES, L.G., RÍOS, H. AND GUELMAN, L.R.
Revista:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Editorial:
Elsevier
Referencias:
Año: 2008 vol. 72 p. 895 - 904
ISSN:
0147-6513
Resumen:
Neonatal ionizing radiation exposure has been shown to induce a
cerebellar cytoarchitecture disarrangement. Since cerebellar abnormalities have
been linked to an impairment of behavioral functions, the aim of the present
work was to investigate whether exposure of developing rats to ionizing
radiations can produce behavioral deficits in the adult. Male Wistar rats were
X-irradiated with 5Gy within 48 h after birth and were tested in a radial maze
and in an open field at 30 and 90 days post irradiation. Irradiated rats showed
significative changes in spatial, exploratory, and procedural parameters in the
radial maze, as well as a significative decrease in anxiety-like behavior,
assessed in the open field. These results suggest that ionizing radiations can
induce long-lasting spatial memory and anxiety- related changes. A relationship
with radiation-induced cerebellar cytoarchitecture abnormalities supports the
hypothesis that cerebellar integrity seems to be critical to achieve spatial
performance and emotional behavior establishment.