Comparative matrix metalloproteinase-2 and -9 expression and activity during endotheliochorial and hemochorial trophoblastic invasiveness

GUALDONI G; GIMENA GOMEZ CASTRO; HERNANDEZ R; BARBEITO C; CEBRAL E

TISSUE & CELL

CHURCHILL LIVINGSTONE

Lugar: ESCOCIA; Año: 2021 vol. 74

0040-8166

To establish a functional placenta, its development needs adequate trophoblastic invasiveness. The intricate and complex morphological and molecular aspects that regulate trophoblastic invasion during the endotheliochorial placentation of domestic carnivores and their similarities and differences with the hemochorial placenta are still poorly understood. During the placentation processes, from the time of implantation, the trophoblast cells invade the uterine endometrium and reach the uterine endometrium to extensive degradation and remodeling of the extracellular matrix components, in which the matrix metalloproteinases (MMPs), particularly MMP-2 and 9, have an essential role in rebuilding, cell migration, and invasiveness. This review aims to give an overview of comparative trophoblast invasive events and the expression and activity of MMP-2 and 9 during endotheliochorial and hemochorial placentation, emphasizing in the dog and mouse placental models. Understanding of the trophoblastic invasiveness in two models of placentation, the intermediate invasive domestic carnivores endotheliochorial placenta, and the higher invasive mouse hemochorial placenta, contributes to the deepening of knowledge of the trophoblast invasive processes and the diverse and complex human placental alterations, such as preeclampsia.