INVESTIGADORES
DIAZ FLAQUE Maria Celeste
artículos
Título:
Activation of Stat3 by Heregulin/ErbB-2 through the Co-Option of
Autor/es:
CJ PROIETTI; C ROSEMBLIT; W BEGUELIN; MA RIVAS; MC DÍAZ FLAQUÉ; EH CHARREAU; R SCHILLACI; PV ELIZALDE
Revista:
MOLECULAR AND CELLULAR BIOLOGY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Año: 2009 p. 1249 - 1265
ISSN:
0270-7306
Resumen:
Cross talk between the steroid hormone receptors for estrogen and progesterone (PR) and the ErbB family of receptor tyrosine kinases appears to be a hallmark of breast cancer growth, but its underlying mechanism remains poorly explored. Here we have highlighted signal transducer and activator of transcription 3 (Stat3) as a key protein activated by heregulin (HRG), a ligand of the ErbB receptors, through co-opted, ligandindependent PR function as a signaling molecule. Stat3 activation was an absolute requirement in HRGinduced mammary tumor growth, and targeting Stat3 effectively inhibited growth of breast cancer cells with activated HRG/ErbB-2 and PR. Our findings unravel a novel potential therapeutic intervention in PR- and ErbB-2-positive breast tumors, involving the specific blockage of PR signaling activity.
