INVESTIGADORES
LUCANGIOLI Silvia Edith
artículos
Título:
A new calcium releasing nano-composite biomaterial for bone tissue engineering scaffolds
Autor/es:
CATTALINI JUAN; GARCIA J.; BOCCACCINI A.; LUCANGIOLI S.,; MOURINO V.
Revista:
Procedia Engineering
Editorial:
ELSEVIER
Referencias:
Lugar: Filadelfia; Año: 2013 vol. 59 p. 78 - 84
ISSN:
1877-7058
Resumen:
A biomaterial with bioactive glass nanoparticles (nBG) and Ca2+ incorporated into alginate matrix was developed. Films
characterization was carried out by SEM, IR, tensile strength measurements, bioactivity assay, degradation and swelling
studies. Ca2+ release from films was analyzed. Freeze-dried-scaffolds were also fabricated. Films showed the development of a
homogeneous matrix and the mechanical properties were improved when nBG were incorporated. The bioactive nature of nBG
containing films was confirmed by studies in simulated body fluid. Degradation was negligible and a good swelling capacity
was observed. Moreover Ca2+ was released in a controlled manner. In scaffolds fabricated by freeze-drying, pores were seen to
be uniform and well distributed. According to the characterization results, these composite biomaterials are attractive candidates
for the fabrication of bone tissue engineering scaffolds2+ incorporated into alginate matrix was developed. Films
characterization was carried out by SEM, IR, tensile strength measurements, bioactivity assay, degradation and swelling
studies. Ca2+ release from films was analyzed. Freeze-dried-scaffolds were also fabricated. Films showed the development of a
homogeneous matrix and the mechanical properties were improved when nBG were incorporated. The bioactive nature of nBG
containing films was confirmed by studies in simulated body fluid. Degradation was negligible and a good swelling capacity
was observed. Moreover Ca2+ was released in a controlled manner. In scaffolds fabricated by freeze-drying, pores were seen to
be uniform and well distributed. According to the characterization results, these composite biomaterials are attractive candidates
for the fabrication of bone tissue engineering scaffolds2+ release from films was analyzed. Freeze-dried-scaffolds were also fabricated. Films showed the development of a
homogeneous matrix and the mechanical properties were improved when nBG were incorporated. The bioactive nature of nBG
containing films was confirmed by studies in simulated body fluid. Degradation was negligible and a good swelling capacity
was observed. Moreover Ca2+ was released in a controlled manner. In scaffolds fabricated by freeze-drying, pores were seen to
be uniform and well distributed. According to the characterization results, these composite biomaterials are attractive candidates
for the fabrication of bone tissue engineering scaffolds2+ was released in a controlled manner. In scaffolds fabricated by freeze-drying, pores were seen to
be uniform and well distributed. According to the characterization results, these composite biomaterials are attractive candidates
for the fabrication of bone tissue engineering scaffolds